We have a proprietary dosing algorithm that helps us determine patients' starting doses based on a number of factors, including bodyweight, psychiatric conditions, prior experience with ketamine or other psychedelics, and overall comfort level.
Generally, the typical starting dose of oral ketamine at Innerwell can range from 100-400mg, which approximates a typical IV dose for depression. For patients who are nervous about undergoing a ketamine experience, we may start at a lower dose of 50mg to help them become familiar and comfortable with the effects of ketamine. Your first two doses will serve as a dose finding exercise, after which your clinician may titrate up or down based on your initial two medicine experiences.
Ultimately, our approach to starting doses helps our psychiatric clinicians and patients understand an individual's sensitivity to ketamine. Sensitivity to ketamine is used to guide future dose adjustments, when needed.